Usually, hypertension is treated with thiazide diuretics, ACE inhibitors, Angiotensin II receptor blockers, calcium channel blockers. When you are not able to reach the normal BP with the above medicines, your health care professional may recommend you Alpha, Alpha-beta blockers, beta-blockers, Renin inhibitors, Aldosterone antagonists, Central-acting agents, Vasodilators.
When your blood pressure stays stubbornly high despite taking at least three variants, out of which one must be diuretic, you will be treated as a “Resistant Hypertensive Patient”. If you fall under the category, then your doctor will evaluate the underlying cause. He will consider adding an aldosterone antagonist such as spironolactone (Aldactone). It might help to control resistant hypertension.